Research progress on RLRs in the treatment of multiple sclerosis
10.11958/58834
- VernacularTitle:RLRs治疗多发性硬化症的研究进展
- Author:
Lu LIU
;
Fangteng DU
;
Yi WEN
;
Jixiang ZHANG
- Publication Type:Journal Article
- Keywords:
multiple sclerosis;
interferon typeⅠ;
review;
RIG-Ⅰ-like receptor;
IPS
- From:
Tianjin Medical Journal
2016;44(1):117-120
- CountryChina
- Language:Chinese
-
Abstract:
At present, the etiology and pathogenesis of multiple sclerosis are unclear. RIG-Ⅰ-like receptors are a new-ly discovered pattern recognition receptors (RLRs), which are located in cytoplasm. They can recognize the helicase of viral dsRNAs, and interact with interferon beta promoter stimulator (IPS)-1 through their caspase activation recruitment domain (CARD), then form IPS-1 signalsome and induce the expression of interferon typeⅠ(Ⅰ-IFN), thereby initiate innate im-mune response and induce antiviral response. Recent studies have found that mice lacking IPS-1 would develop exacerbated disease and accompanied by markedly higher inflammation, increasing axonal damage and demyelination. Furthermore, initi-ating the RIG-Ⅰ-like helicase receptor on the immune cells can alleviate inflammation and myelin fracture in multiple scle-rosis of mouse model, thus limit the incidence of paralysis. This paper is a review about the research progress on RLRs in the treatment of multiple sclerosis.
