Therapeutic effect of repaglinide on patients with type 2 diabetes mellitus complicated atherosclerosis
10.3969/j.issn.1008-0074.2016.02.22
- VernacularTitle:瑞格列奈治疗2型糖尿病并动脉硬化患者的疗效
- Author:
Qiang JIAN
;
Jia LI
;
Pengfei LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Atherosclerosis;
Treatment outcome;
Repaglinide
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2016;25(2):192-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore therapeutic effect of repaglinide on patients with type 2 diabetes mellitus (T2DM) complicated atherosclerosis (AS).Methods:A total of 120 T2DM + AS patients treated in our hospital from Mar 2012 to May 2014 were selected.They were randomly and equally divided into repaglinide group (received repaglin- ide treatment)and glipizide group (received glipizide treatment).Fasting blood glucose (FBG)and 2h postprandial blood glucose (2hPG)levels before and after treatment,serum levels of high sensitive C reactive protein (hsCRP) and oxidized low density lipoprotein (oxLDL)after treatment,and patients'satisfaction on treatment were com- pared and analyzed between two groups.Results:Compared with before treatment,there were significant reductions in levels of FBG and 2hPG in both groups after treatment (P<0.01 all);compared with glipizide group,there were significant reductions in levels of FBG [(6.94±0.41)mmol/L vs.(6.05±0.54)mmol/L],2hPG [(8.03±0.74) mmol/L vs.(7.66±0.78)mmol/L],serum hsCRP [(5.75±0.26)mg/L vs.(4.71±0.32)mg/L]and serum ox- LDL [(98.30±25.05)μg/dl vs.(52.21±17.50)μg/dl]after treatment in repaglinide group,P<0.01 all.Satis- faction rate in repaglinide group was significantly higher than that of glipizide group (93.33% vs.60.00%),P<0.01. Conclusion:Repaglinide possesses significant therapeutic effect on patients with type 2 diabetes mellitus com- plicated atherosclerosis.It can significantly reduce blood glucose,blood lipid and serum hsCRP levels.
