The occurrence of chemotherapy-induced amenorrhea in postoperative and premenopausal patients with breast cancer and its influencing factors
10.3760/cma.j.issn.1006-9801.2016.01.007
- VernacularTitle:绝经前乳腺癌患者术后化疗致闭经的发生及其影响因素
- Author:
Hu XU
;
Fang ZHANG
;
Deqiang KOU
;
Jiandong WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Chemotherapy;
Ovarial function;
Amenorrhea
- From:
Cancer Research and Clinic
2016;28(1):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of postoperative chemotherapeutic regimens on menstruation in pre-menopausal patients with breast cancer. Methods 120 pre-menopausal patients with breast cancer from Jan 2010 to Dec 2012 were followed-up. The occurrence rate and recovery rate of chemotherapy-induced amenorrhea (CIA) were analyzed. The relationship between different chemotherapeutic regimens and CIA of various age groups was analyzed. Results 120 women were followed-up, 94 (78.3 %) patients developed CIA. The frequency of CIA in younger patients (≤ 35 years) was significantly lower than that in patients older than 35 years (P < 0.05). 50 (53.2 %) patients returned to normal menses. The recovery situation of CIA was significantly different among various age groups (P < 0.05). The difference of the occurrence rate of CIA was not statistically significant between the patients who received anthracycline-based chemotherapy and docetaxel-based chemotherapy (P > 0.05). Conclusions Age is an important influence factor of the CIA. Chemotherapy has less influence on the menstruation of younger patients (≤35 years) and most amenorrhea is reversible. The effects of sequential addition of taxanes in chemotherapy and anthracyclines alone on menstruation have no significant difference.
