Changes of serum HMGB1 ,ET-1 and MIF concentrations in patients with T2DM complicated CHD and their correlations with inflammatory factors
10.3969/j.issn.1008-0074.2016.02.05
- VernacularTitle:糖尿病合并冠心病患者血清HMGB1、ET-1、MIF含量变化及其与炎症因子的相关性
- Author:
Guiming ZANG
;
Yi CAO
;
Jie WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Coronary disease;
Inflammation
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2016;25(2):129-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study changes of serum concentrations of high mobility group protein B1 (HMGB1),endo- thelin (ET )-1 and macrophage migration inhibitory factor (MIF ) in patients with type 2 diabetes mellitus (T2DM)complicated coronary heart disease (CHD)and explore their correlations with inflammatory factors.Meth-ods:The 120 patients with T2DM+ CHD treated in our hospital from May 2013 to Sep 2014 were enrolled in obser-vation group,including 30 cases with SAP,30 cases with UAP,30 cases with NSTEMI and 30 cases with STEMI. Another 30 T2DM cases without cardiovascular diseases during the same period were enrolled as pure DM group.En- zyme linked immunosorbent assay was used to measure concentrations of HMGB1,ET-1,MIF,CRP,TNF-α,IL-6, IL-8,IL-17 and IL-23,and they were compared among above groups.Results:Compared with pure DM group, there were significant rise in serum concentrations of HMGB1 [(3.49±0.52)μg/L vs.(9.18±1.02)μg/L],ET- 1 [(104.54±12.56)ng/L vs.(256.56±34.16)ng/L],MIF [(87.78±10.52)ng/L vs.(178.32±21.34)ng/L], CRP [(6.28±0.84)mg/L vs.(16.52±2.15)mg/L],TNF-α[(8.54±1.09)ng/L vs.(21.91±2.76)ng/L],IL- 6 [(2.25±0.34)ng/L vs.(6.34±0.82)ng/L],IL-8 [(7.23±0.94)ng/L vs.(15.41±1.97)ng/L],IL-17 [(65.34±8.32)ng/L vs.(141.62±20.18)ng/L]and IL-23 [(125.22±14.23)ng/L vs.(321.12±41.54)ng/L] in observation group,P<0.05 or <0.01. The serum concentrations of HMGB1,ET-1 and MIF were SAP group
