Changes of plasma levels of catestatin and brain natriuretic peptide in patients with chronic heart fail-ure and their correlation
10.3969/j.issn.1008-0074.2016.02.09
- VernacularTitle:心衰患者血浆儿茶酚抑素和脑钠肽水平变化及其相关性
- Author:
Xiaohui ZHAO
;
Weiqin GAO
;
Jun YANG
- Publication Type:Journal Article
- Keywords:
Heart failure;
Natriuretic peptide,brain;
Catestatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2016;25(2):145-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore changes of plasma levels of catestatin (CST)and brain natriuretic peptide (BNP)in patients with chronic heart failure (CHF)and their correlation.Methods:A total of 60 CHF patients treated in our department of cardiology from Jun 2014 to Dec 2014 were enrolled as CHF group,another 60 healthy subjects un- dergoing physical examination were regarded as normal control group.Enzyme linked immunosorbent assay was used to measure plasma levels of CST and BNP in two groups,then the results were compared.Linear correlation analysis was used to analyze the correlation between plasma levels of CST and BNP.Results:Compared with normal control group,there were significant rise in plasma levels of CST [(0.40±0.15)ng/L vs.(0.88±0.34)ng/L]and BNP [(30.84±12.56)ng/L vs.(678.21±120.35)ng/L]in CHF group,P<0.01 both.Linear correlation analysis indi- cated that plasma CST level was significant positively correlated with BNP level (r=0.38,P<0.05).Conclusion:Catestatin level is significant positively correlated with the most sensitive cardiac function index—brain natriuretic peptide level,suggesting that it could be used as a new biochemical marker diagnosing or excluding heart failure.
