Application of recombinant human brain natriuretic peptide in stress cardiomyopathy complicated acute left heart failure
10.3969/j.issn.1008-0074.2016.02.17
- VernacularTitle:重组人脑利钠肽在应激性心肌病并急性泵衰竭中的应用
- Author:
Hao YU
;
Xiaojun HU
;
Jiao LI
;
Yuzhen SUN
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Takotsubo cardiomyopathy;
Heart failure,systolic
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2016;25(2):176-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe therapeutic effect of lyophilized recombinant human brain natriuretic peptide (Lrh-BNP)on stress cardiomyopathy (SCM)complicated acute bump failure.Methods:A total of 23 patients with SCM complicated acute bump failure were randomly divided into routine treatment group (n=10,received routine treatment)and Lrh-BNP group (n=13,received Lrh-BNP based on routine treatment).Clinical symptoms and signs,cardiac function :left ventricular ejection fraction (LVEF),stroke volume (SV),cardiac index (CI),peak early diastolic velocity/peak late diastolic velocity (E/A)assessed by echocardiography before and after treatment, and total effective rate were compared between two group.Results:Total effective rate of Lrh-BNP group was sig- nificantly higher than that of routine treatment group (92.3% vs.80.0% ,P<0.05).There were no significant difference in cardiac function indexes between two groups before treatment (P>0.05 all);after treatment,com- pared with routine treatment group,there were significant rise in LVEF [(50.2±16.3)% vs.(59.4±14.1)%],SV [(39.5±10.4)ml vs.(48.3±12.5)ml],CI [(3.7±1.1)L min-1 m-2 vs.(4.6±1.4)L min-1 m-2 ]and E/A [(1.0±0.5)vs.(1.3±0.7)]in Lrh-BNP group,P<0.05 all.Conclusion:Lrh-BNP possesses significant thera- peutic effect on stress cardiomyopathy complicated acute left heart failure.
