Therapeutic effect of levosimendan on refractory heart failure

VernacularTitle:左西孟坦治疗顽固性心力衰竭的疗效
Author: Xiaolan ZHANG
Publication Type:Journal Article
Keywords: Heart failure; Treatment outcome; Levosimendan
From: Chinese Journal of cardiovascular Rehabilitation Medicine 2016;25(2):179-182
CountryChina
Language:Chinese
Abstract: Objective:To explore therapeutic effect of levosimendan on refractory heart failure (RHF).Methods:A total of 60 patients,who were diagnosed as RHF in our department of cardiology from Sep 2010 to Sep 2014,were selected.Ac- cording to random number table,they were randomly and equally divided into routine treatment group and levosimendan group (received levosimendan based on routine treatment group).Left ventricular ejection fraction (LVEF),plasma level of brain natriuretic peptide (BNP)before and after treatment,6min walking distance (6MWD)on 60d after treatment and total effective rate were compared between two groups.Results:Total effective rate of levosimendan group was significantly higher than that of routine treatment group (90.0% vs.76.7%,P=0.03).Compared with routine treatment group af- ter treatment,there were significant rise in LVEF [(41.53±3.42)% vs.(48.84±3.57)%]and 6MWD [(371.0±69.5) m vs.(467.2±87.3)m],and significant reduction in plasma BNP level [(453±39)pg/ml vs.(199±27)pg/ml]in levo- simendan group,P<0.05 all.Conclusion:Levosimendan possesses significant therapeutic effect on refractory heart failure without severe adverse reaction,which is worth extending.