Retrospective Study on Magnesium Sulfate Combined with Nifedipine in the Improvement of Preeclampsia Blood Pressure and Pregnancy Outcomes
- VernacularTitle:硫酸镁联合硝苯地平对子痫前期患者血压改善及妊娠结局的回顾性研究
- Author:
Qiaojun JIN
;
Lanjuan MAO
- Publication Type:Journal Article
- Keywords:
Preeclampsia;
Magnesium sulfate;
Nifedipine;
Blood pressure;
Pregnancy outcomes
- From:
China Pharmacist
2016;19(2):311-313
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of magnesium sulfate combined with nifedipine on preeclampsia blood pressure and pregnancy outcomes. Methods:The data of 62 patients with preeclampsia were retrospectively studied. According to the treatment reg-imen, the patients were divided into the control group (30 cases) with magnesium sulfate treatment and the observation group (32 ca-ses) with magnesium sulfate combined with nifedipine treatment. The blood pressure before and after the treatment, as well as the clin-ical efficacy, pregnancy complications and pregnancy outcomes in the two groups were compared. Results:After the treatment, systolic and diastolic blood pressure of the patients in the two groups were significantly lowered when compared with those before the treatment (P<0. 05), and the decrease in the observation group was more significant than that in the control group (P<0. 05). The total effec-tive rate of the observation group was 96. 88%, which was significantly higher than that of the control group (73. 33%, P<0. 05). The incidence of uterine inertia, postpartum hemorrhage, fetal distress and placental abruption in the observation group was significant-ly lower than that in the control group (P<0. 05), and the rate of cesarean section and neonatal asphyxia in the observation group was also significantly lower than that in the control group(P<0. 05). Conclusion:Magnesium sulfate combined with nifedipine in the treat-ment of preeclampsia shows notable antihypertensive effect, which can reduce the incidence of pregnancy complications and adverse pregnancy outcomes. Therefore, the combination exhibits better efficacy than magnesium sulfate alone.
