Effects of TCM Periodic Therapy on Sex Hormone, Glucose and Lipid Metabolism of Patients with Polycystic Ovary Syndrome
10.3969/j.issn.1005-5304.2016.01.008
- VernacularTitle:中药周期疗法对多囊卵巢综合征患者性激素和糖脂代谢的影响
- Author:
Bihong XU
;
Maoqing LI
;
Chunling CHEN
;
Yuji LUO
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
TCM periodic therapy;
sex hormone;
glucose and lipid metabolism
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;(1):35-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of TCM periodic therapy combined with estradiol progesterone tablets (Diane-35) in the treatment for polycystic ovary syndrome (PCOS), and its effects on serum sex hormone, glucose and lipid metabolism.Methods Totally 74 patients with PCOS were randomly divided into Western medicine (WM) group and Chinese and Western medicine (CWM) group, 37 cases in each group. WM group was given Diane-35, while CWM group was treated with TCM periodic therapy additionally, for three courses, 28 d of one course. Clinical symptoms, sex hormones and glucose and lipid metabolism of two groups were observed before and after treatment and withdrawal treatment for 3 months.Results Two patients in each group were lost to follow-up. Markedly effective rate and total efficiency rate of CWM group were better than WM group (P<0.05). After treatment, symptom integrals of CWM group decreased significantly (P<0.01). Serum E2 increased (P<0.01), while LH, T and LH/FSH decreased in two groups (P<0.01). After treatment and withdrawal treatment for 3 months, improvement of clinical symptoms and sex hormone levels in CWM group was superior to CM group (P<0.01), FPG, FINS, TG, TC and BMI of CWM group decreased in CWM group (P<0.05), and lower than that of CM group (P<0.05,P<0.01). Adverse reaction rates of WM group and CWM group were 17.1% and 5.71% (P<0.05).Conclusion Efficacy of TCM periodic therapy combined with Diane-35 in treatment of PCOS is significant, which can obviously improve patients’ clinical symptoms, and regulate hormone and lipid metabolism disorders, with fewer adverse reactions.
