Association between CMTM5 gene rs723840 single nucleotide polymorphism and high on asprin platelet reactivity
10.3969/j.issn.1671-167X.2015.06.003
- VernacularTitle:CMTM5基因rs723840单核苷酸多态性与阿司匹林治疗下血小板高反应性的相关性研究
- Author:
Tengfei LIU
;
Jingwei ZHANG
;
Xiahuan CHEN
;
Xueru FENG
;
Zhongsheng BAI
;
Meilin LIU
- Publication Type:Journal Article
- Keywords:
Platelet aggregation;
CMTM5;
Polymorphism;
single nucleotide;
Aspirin
- From:
Journal of Peking University(Health Sciences)
2015;47(6):905-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To elucidate the correlation between the single nucleotide polymorphism of CKLF-like MARVEL transmembrane member 5 ( CMTM5 ) gene rs723840 and the occurrence of high on aspirin platelet reactivity ( HAPR) . Methods:The present study is a case-control study. A total of 210 hospitalized patients in Peking University First Hospital were enrolled. Aspirin response was assessed by 0. 5 g/L arachidonic acid (AA)-induced platelet aggregation ratio (PR), and ≥3/4 quartile of PR of the population was defined as HAPR. Accordingly all the enrolled 210 coronary artery diseases ( CAD) patients were divided into HAPR group and No-HAPR group. The genotypes were determined by poly-merase chain reaction ( PCR) and sequencing analysis for rs723840 of CMTM5 gene. Results:The geno-type frequencies in rs723840 C>T of CMTM5 gene conformed well to the Hardy-Weinberg equilibrium in both HAPR group and No-HAPR group. Between the two groups, the genotypes frequencies in HAPR and No-HAPR groups were 48 . 4%, 51 . 6%, 0 . 0% and 73 . 7%, 22 . 9%, 0 . 034%, respectively ( P=0. 004). The C, T allele frequencies were significantly different in the two groups (P =0. 031,OR =0 . 501 , 95%CI:0 . 264-0 . 947 ) . Conclusion:Our study finds a significant correlation between CMTM5 gene rs723840 polymorphism and high on aspirin platelet reactivity.
