Research progress on absent in melanoma 2 in defending pathogenic microorganism invasion
10.3760/cma.j.issn.1674-2397.2016.01.017
- VernacularTitle:黑色素瘤缺乏因子2炎性体在抗微生物感染中的研究进展
- Author:
Di MA
;
Xinglou LIU
;
Feng FANG
- Publication Type:Journal Article
- Keywords:
Absent in melanoma 2;
Cysteinyl aspartate specific proteinase-1;
Apoptosis-associated speck-like protein;
Interleukin-18;
Interleukin -1β;
Pathogenic microorganism
- From:Chinese Journal of Clinical Infectious Diseases
2016;(1):87-91
- CountryChina
- Language:Chinese
-
Abstract:
Innate immunity is on the frontline of fight against pathogenic microorganism invasion .As a DNA sensor, absent in melanoma 2 (AIM2) is an important member of innate immune system.It can recognize dsDNA of pathogenic microbes to form AIM 2 inflammasomes , which facilitates defending and clearing the invasion of pathogens by activating caspase-1 dependent pyroptosis and the mature of IL-18 and IL-1β.AIM2 inflammasomes play an important part in responding to Listeria monocytogenes, Francisella tularensis, Streptococcus pneumoniae, Mycobacterium tuberculosis, Aspergillus fumigatus, vaccinia virus , murine cytomegalovirus , and hepatitis B virus infections .This paper introduces the components of AIM 2 inflammasomes and summarizes its function in defending the invasion of pathogenic microorganisms .
