Advances in nucleotide reductase inhibitors for antiviral therapy
10.3760/cma.j.issn.1674-2397.2016.01.016
- VernacularTitle:核糖核苷酸还原酶抑制剂的抗病毒作用研究进展
- Author:
Yan LOU
;
Zhe WU
;
Jimin SHAO
;
Yunqing QIU
- Publication Type:Journal Article
- Keywords:
Ribonucleotide reductases;
Enzyme inhibitors;
Antiviral treatment;
Clinical application
- From:Chinese Journal of Clinical Infectious Diseases
2016;(1):83-86
- CountryChina
- Language:Chinese
-
Abstract:
Ribonucleotide reductase ( RR ) is a rate-limiting enzyme, and it is responsible for reducing ribonucleotides to their corresponding deoxyribonucleotides , which are the building blocks required for DNA replication and repair .Recent studies have revealed that RR activity is associated with DNA replication in virus , and RR inhibitors have been used for clinical antiviral treatment .This paper reviews research progress on RR and its inhibitors , including the classification , structure and function of RR; the classification, mechanism and clinical application of RR inhibitors in antiviral therapy and the future prospects of RR inhibitors .
