Combination of autologous bone marrow stem cell transplantation anddanggui huoxue tang for treatment of diabetic foot
10.3969/j.issn.2095-4344.2015.50.018
- VernacularTitle:自体骨髓干细胞移植联合当归活血汤治疗糖尿病足
- Author:
Haitao MA
;
Tao ZHOU
;
Wenmiao QIU
;
Ping LIU
- Publication Type:Journal Article
- Keywords:
Diabetic Foot;
Angelica sinensis;
Stem Cel Transplantation;
Bone Marrow;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2015;(50):8139-8143
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:In recent years, the incidence of diabetic foot is sharply increasing, which tends to cause foot ulcers, amputation and death.
OBJECTIVE:To investigate the clinical therapeutic effect of autologous bone marrow stem cel transplantation combined withdanggui huoxue tangon diabetic foot.
METHODS:Sixty patients with diabetic foot accompanied by chronic lower limb ischemia were randomly divided into conventional treatment group including 20 cases with 38 affected limbs, and autologous bone marrow stem cel transplantation group (cel transplantation group) including 20 cases with 36 affected limbs, and combined group (autologous bone marrow stem cel transplantation combined withdanggui huoxue tang) including 20 cases with 39 affected limbs. After 12 weeks of treatment, indicators such as limb cold-feeling, pain, skin temperature, claudication distance and ankle brachial index were measured, and meanwhile, complications and adverse reactions were observed in the folow-up visit.
RESULTS AND CONCLUSION: In the conventional treatment group, there was no significant change before and after treatment (P > 0.05). However, these indicators were significantly improved in the other two groups after treatment (P < 0.05) as wel as compared with the conventional treatment group (P < 0.05). In addition, there was no adverse reaction in the cel transplantation group. These findings indicate that the combination of autologous bone marrow stem cel transplantation anddanggui huoxue tang has effective effects on diabetic foot.
