Research on effects of argatroban combined with Kallikrein on progressive cerebral infarction
10.3969/J.ISSN.1672-8270.2016.01.034
- VernacularTitle:阿加曲班联合尤瑞克林治疗进展性脑梗死疗效对比研究
- Author:
Junzeng SI
;
Xiuling GUO
;
Qinde QI
- Publication Type:Journal Article
- Keywords:
Argatroban;
Kallikrein;
Progressive cerebral infarction
- From:
China Medical Equipment
2016;13(1):108-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of argatroban combined with Kallikrein on progressive cerebral infarction.Methods: One hundred and fifty two progressive cerebral infarction patients were randomized into groups observation (n=76) and control (n=76). Observation group were given treatment ofargatroban and Kallikrein, control only Kallikrein. NIHSS scores, Barthel index, Modified Rankin Scales(MRS) were used to evaluate the efficacy in two groups.Results: The difference of the effect was significant in two groups(x2=11.463,P>0.05).In both of the two groups, NIHSS scores were decreased, there was significant difference between the two groups (t=1.501,t=1.844,t=1.341;P<0.05). The Barthel index in argatroban combined Kallikrein group was higher than Kallikrein group, Modified Rankin Scales was lower than Kallikrein group, and there was significant difference between the two groups (t=2.121,t=2.332,t=2.219;P<0.05). The observation group and the control group patients don''t have bleeding gums,subcutaneous bleeding, gastrointestinal bleeding and other adverse reactions.Conclusion: Argatroban combined with Kallikrein, improve the neurologic impairment symptoms, clinical effect, improve the life quality of the patients, of a relatively good effect in treatment of progressive cerebral infarction, can improve obviously the cognitive ability and neural function and patients, activities of daily living. Moreover, its security and tolerability are good.
