Prognostic Value of Soluble ST2 During Hospitalization for ST-Segment Elevation Myocardial Infarction.
10.3343/alm.2016.36.4.313
- Author:
Olga BARBARASH
1
;
Olga GRUZDEVA
;
Evgenya UCHASOVA
;
Yulia DYLEVA
;
Ekaterina BELIK
;
Olga AKBASHEVA
;
Victoria KARETNIKOVA
;
Aleksandr SHILOV
Author Information
1. Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russian Federation. evg.uchasova@yandex.ru
- Publication Type:Original Article
- Keywords:
Myocardial infarction;
NT-proBNP;
sST2
- MeSH:
Area Under Curve;
Case-Control Studies;
Electrocardiography;
Enzyme-Linked Immunosorbent Assay;
Female;
Hospitalization;
Humans;
Logistic Models;
Male;
Middle Aged;
Myocardial Infarction/*diagnosis/diagnostic imaging;
Natriuretic Peptide, Brain/blood;
Odds Ratio;
Peptide Fragments/blood;
Prognosis;
Proportional Hazards Models;
ROC Curve;
Receptors, Somatostatin/*blood
- From:Annals of Laboratory Medicine
2016;36(4):313-319
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications. METHODS: We included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups: the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA. RESULTS: On day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004). CONCLUSIONS: The level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP.
