Recent advances in the quantification of drug metabolizing enzymes and transporters by proteomic approach.
- Author:
Bo YANG
;
Jing WANG
;
Yuting CONG
;
Lianghai HU
;
Jingkai GU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2015;50(6):668-74
- CountryChina
- Language:Chinese
-
Abstract:
With the advance of drug development and research techniques, the drug metabolic processes and mechanism can be more deeply achieved. As the drug metabolism and pharmacokinetics process are mediated by drug metabolizing enzymes and transporters, study of drug metabolizing enzymes and transporters has become an important part for drug development. The traditional immunoassays with low sensitivity and poor specificity can not reflect the accurate expression level of drug metabolizing enzymes and transporters. We now give a brief review on the quantitative study of drug metabolizing enzymes and transporters by mass spectrometry-based proteomic approach.
