Effect of rebeparzole sodium enteric-coated capsules, amoxicillin and clavulanate potassium tablets and furazolidon or levofloxacin treatment of helicobacter pylori infection
10.3760/cma.j.issn.1008-6315.2015.12.020
- VernacularTitle:雷贝拉唑钠肠溶胶囊与阿莫西林克拉维酸钾分散片联合呋喃唑酮治疗幽门螺杆菌感染效果观察
- Author:
Jingdong WANG
;
Bin CAO
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Rebeparzole;
Levofloxacin;
Furazolidon;
Amoxicillin and clavulanate potassium tablets
- From:
Clinical Medicine of China
2015;31(12):1120-1124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of treatment and compliance of rebeparzole sodium enteric coated capsules, amoxicillin and clavulanate potassium tablets and furazolidon or levofloxacine treatment of helicobacter pylori infection.Methods Two hundred and forty-nine cases of positive helicobacter pylori infection were randomly divided into three groups.Eighty-one cases of Group A were treated with rebeparzole sodium enteric-coted capsules (20 mg one time), amoxicillin and clavulanate potassium tablets (3 tablets one time) and furazolidon(100 mg one time) ,twice a day before breakfast and supper.Eighty-three cases of Group B were treated with rebeparzole sodium enteric-coted capsules (20 mg one time), amoxicillin and clavulanate potassium tablets (3 tablets one time) and levofloxacine (200 mg one time), twice a day before breakfast and supper.Eighty-five cases of Group C were treated with rebeparzole sodium enteric-coted capsules (20 mg one time) ,clarithromycin capsules(500 mg one time) and amoxicillin dispersible tablets(1 000 mg one time) ,twice a day before breakfast and supper.Period of treatment was 10 days.Results The helicobacter pylori eradication rate of Group A,B and C were 93.83％(76/81) ,89.16％(74/83) and 81.18％(69/85).The eradication rate of Group A was higher than that of Group C (P＜0.05).The comparison between Group A and Group B and between Group B and Group C had no statistically significant difference(P＞0.05).Total integral in average of main digestive symptoms respectively decreased from 12.52±2.24, 12.30±2.42,12.61±2.01 to 3.16±2.23, 3.58±2.39,4.78±2.28 after four-week treatment.The effect of treatment of Group A and Group B was much better than that of Group C(P＜0.05).The incidence of adverse reaction were 11.11％, 30.12％ and 62.35％respectively.Group A and Group B were much lower than Group C (P ＜ 0.05), and Group A was lower than Group B(P＜0.05).In the comparison of the spread of compliance, Group A was the best, the next was Group B,and the last was Group C.The comparison result of those 3 groups was statistically significant (P ＜0.05).Conclusion Ray rabeprazole sodium enteric coated capsules and amoxicillin and clavulanate potassium dispersion tablets combined with furazolidone furazolidone triple therapy in the treatment of Helicobacter pylori Helicobacter pylori infection effect is the best.
