Analysis of the national verification for hemoglobin A1e test trueness among different measuring systems
10.3760/cma.j.issn.1009-9158.2015.11.007
- VernacularTitle:全国糖化血红蛋白正确度验证室间质评不同检测系统的结果分析
- Author:
Xiaoyan ZHANG
;
Wei WANG
;
Haijian ZHAO
;
Chuanbao ZHANG
;
Zhiguo WANG
- Publication Type:Journal Article
- Keywords:
Hemoglobin A,glycosylated;
Laboratory proficiency testing;
Quality control;
Quality assurance,health care
- From:
Chinese Journal of Laboratory Medicine
2015;38(11):742-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the results of different measuring procedures of hemoglobin A1c (HbA1c) trueness verification scheme in China.Methods Cross sectional survey.The data were collected via the External Quality Assessment (EQA) software from laboratories participated in the First HbA1c trueness verification EQA.Then the collected data were divided into several groups based on laboratory instruments and the data from less than 5 group were excluded.The observed imprecision, bias and sigma (σ) were calculated and the bias％ and CV％ were drew in the sigma chart.The average bias％, CV％ and weighted average σ of each level were also calculated.Results Total 123 laboratories were divided into 9 groups and setting 6％ as the Allowable Total Error, the average bias％, CV％ and weighted average σ of 201411 (target value was 5.4％) were 3.70％, 4.55％ and 0.51 respectively σ, of 201412 (target value was 7.8％)were 2.42％ , 3.56％ and 1.24σ respectively.None of the group achieved the 2σ quality of 201411, and 1 group achieved the 2σ quality of 201412.Conclusions There are obvious biases among the results of many measuring systems and the target value assigned by reference measuring procedures of HbA1c, as well as the imprecision.The Sigma External Quality Assessment Chart is a visual tool, indicating that the quality of measuring systems necessitate improvement therefore to ensure the reliability of results and make better use of HbA1c in clinical application.
