Effects of dexmedetomidine on expression of TLR2 and TLR4 in monocytes of blood during perioperative period in patients undergoing pulmonary lobectomy
10.3760/cma.j.issn.0254-1416.2015.09.003
- VernacularTitle:右美托咪定对肺叶切除术患者围术期血液单核细胞TLR2和TLR4表达的影响
- Author:
Yanfei LIU
;
Li CONG
;
Fei SHI
;
Bin WANG
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Toll-like receptor 2;
Toll-like receptor 4;
Monocytes;
Blood;
Pneumonectomy
- From:
Chinese Journal of Anesthesiology
2015;35(9):1044-1046
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of dexmedetomidine on the expression of Toll-like receptor 2 (TLR2) and TLR4 in monocytes of blood during the perioperative period in the patients undergoing pulmonary lobectomy.Methods Fifty patients of both sexes, aged 40-64 yr, with body mass index of 20-24 kg/m2 , of ASA physical status Ⅰ or Ⅱ , scheduled for elective pulmonary lobectomy under general anesthesia, were randomized into 2 groups (n =25 each) using a random number table: control group (group C) and dexmedetomidine group (group D).In group D, dexmedetomidine was infused intravenously at dose of 1.0 μg/kg over 10 min before induction of anesthesia, followed by continuous infusion at a rate of 0.3 μg · kg-1 · h-1 until 30 min before the end of operation, while the equal volume of normal saline was given in group C.After admission to the operating room, at 1.5 h after beginning of operation, at the end of operation, and at 12 and 24 h after operation, blood samples were taken for blood gas analysis, and for determination of the expression of TLR2 and TLR4 in monocytes.Oxygenation index was calculated.The consumption of propofol and remifentanil and pulmonary complications within 48 h after operation were recorded.Results Compared with group C, the expression of TLR2 and TLR4 in monocytes of venous blood was significantly down-regulated, oxygenation index was increased, and the incidence of pulmonary complications after operation was decreased in group D (P＜0.05).Conclusion The mechanism by which dexmedetomidine attenuates acute lung injury is associated with down-regulation of TLR2 and TLR4 expression in monocytes of blood in the patients undergoing pulmonary lobectomy.
