Diagnostic value of Matrix metalloproteinase-9 and Epidermal growth factor in uterine myoma

VernacularTitle:血清基质金属蛋白酶9、表皮生长因子检测对子宫肌瘤的诊断价值
Author: Lijuan CAO ; Yanan YUAN ; Guoyi DANG ; Qiong WU ; Hui WAN ; Zhimin LI
Publication Type:Journal Article
Keywords: Uterine myoma; Matrix metalloproteinase-9; Epidermal growth factor; Value
From: Clinical Medicine of China 2015;31(12):1065-1067
CountryChina
Language:Chinese
Abstract: Objective To discuss the diagnostic value of Matrix metalloproteinase-9 (MMP-9) and Epidermal growth factor (EGF) in uterine myoma.Methods Seventy-three patients with uterine leiomyoma treated by surgery as treatment group,and 65 healthy women were selected as control group.The levels of MMP9 and EGF in both groups were detected by enzyme-linked immunosorbent assay method.Results The levels of MMP-9and EGF in treatment group were significantly higher than those of control group((1.72±0.36) mg/L vs.(1.28±0.25) mg/L, (342.16± 128.65) ng/L vs.(209.84± 100.34) ng/L;t =8.241,6.678;P ＜0.01).There were no relationships between the levels of MMP-9 and EGF with maximum diameter of uterine myoma (P ＞0.05).Conclusion Serum levels of MMP-9 and EGF have some clinical value in diagnosing uterine leiomyoma.