Survival analysis of elderly patients with hypoproliferative acute myeloid leukemia by CAG-induction and post-remission intensive chemotherapy
10.3760/cma.j.issn.1008-6315.2015.12.011
- VernacularTitle:老年低增生性急性髓细胞白血病CAG诱导及缓解后强化治疗生存分析
- Author:
Zhengyi ZHANG
;
Yuhua ZHU
;
Hongjian MA
;
Yongjun LI
- Publication Type:Journal Article
- Keywords:
Hypoproliferative acute myeloid leukemia in elderly;
CAG;
Intensive chemotherapy
- From:
Clinical Medicine of China
2015;31(12):1089-1092
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Explore the therapy of elderly patients with hypoproliferative acute myeloid leukemia.Methods Twenty-six elderly patients with hypoproliferative acute myeloid leukemia had received induction of CAG regimen and 15 cases were treated intensive chemotherapy after complete remission,then if achieving complete remission had received subsequent intensive chemotherapy: stand or reduce AA, DA or HA regimen.Results In 26 cases patients who received CAG regimen,the complete remission rate, partial remis sionrat and the totle total effective rate were 53.85％ (14/26), 19.23％ (5/26) and 73.08％ (19/26), respectively.Accordance with response to CAG regimen and the therapy after complete remission, 26 patients were divided into 3 groups:intensive chemotherapy after complete remission(CR1), non-intensive chemotherapy after complete remission(CR2) and non-remission(NR, including partial remission patients).The median overall survival of CR1 ,CR2 and NR were 13.5 months, 8.2 months, and 4.5 months, respectively.There was higher median overall survival of CR1 group than CR2 and NR groups (P =0.041,0.001, respectively).There was higher OS of CR2 group than NR group (P =0.064).No serious bleeding events were found in chemotherapy.Conclusion CAG regimen was an effective and little adverse effect regimen for the treatment of elderly H-AML,and with well tolerance in patients.Advisable intensive chemotherapy can prolong the patient's survival time after complete remission.
