Prediction and bioinformatic analysis of hsa-miRNA-451 target genes

VernacularTitle:hsa-miRNA-451靶基因预测及生物信息学分析
Author: Zhenna CHEN ; Yan SHAO ; Xiaorong LI
Publication Type:Journal Article
Keywords: Gene therapy; Forecasting; Computational biology; Diabetic retinopathy/physiopathology
From: Chinese Journal of Ocular Fundus Diseases 2015;31(6):597-599
CountryChina
Language:Chinese
Abstract: Objective To predict as well as bioinforrmatically analyze the target genes of has-miR-451.Methods miRBase, miRanda, TargetScan and PicTar were used to predict the target genes of hsa-miRNA-451.The functions of the target genes were demonstrated by Gene Ontology and pathway enrichment analysis.P＜0.05 was set as statistically significant.Results 18 target spots of hsa-miRNA-451 were predicted by 3 databases or prediction software at least.The functions of the target genes were enriched in proliferation and development of epithelial cells and regulation of kinase activity (P＜ 0.05).Pathway analysis showed that transforming growth factor-beta signaling pathway, mitogen-activated protein kinase signaling pathway, epidermal growth factor signaling pathway, Wnt signaling pathway and mammalian target of rapamycin signaling pathway were significantly enriched (P＜0.05).Conclusion hsa-miRNA-451 might be involved in various signaling pathways related to proliferation and development of epithelial cells.