Mechanism of alternative splicing and its application in diagnosis and treatment of leukemia
10.3760/cma.j.issn.1009-9158.2015.11.004
- VernacularTitle:选择性剪接机制及其在白血病诊疗中的应用
- Author:
Jing LIU
;
Jing ZHANG
;
Bo HUANG
;
Xiaozhong WANG
- Publication Type:Journal Article
- Keywords:
Leukemia;
Alternative splicing;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2015;38(11):730-732
- CountryChina
- Language:Chinese
-
Abstract:
Alternative splicing is a process refering a pre-mRNA transforms to different mature mRNAs by different splicing sites combination, and then the mRNAs translate to various proteins.This process is regulated by a variety of cis acting elements and trans acting factors.Recent studies have shown that aberrant alternative splicing is prevalent in leukemia patients, and is closely associated with leukemic occurrence, development and chemotherapy resistance.This shows us that aberrant altemative splicing may be helpful to leukemia diagnosis and treatment.
