Progresses of kv1.3 potassium channel and its related diseases
10.3760/cma.j.issn.1673-4408.2015.06.001
- VernacularTitle:Kv1.3钾离子通道及其与相关疾病的研究进展
- Author:
Qianlan ZHOU
- Publication Type:Journal Article
- Keywords:
Kv1.3 potassium channel;
T lymphocyte;
Autoimmune disease;
Tumor
- From:
International Journal of Pediatrics
2015;42(6):603-606
- CountryChina
- Language:Chinese
-
Abstract:
Kvl.3 potassium channel plays a key role in T lymphocyte activation.In many diseases mediated by T lymphocytes, such as multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, anti-glomerular basement membrane glomerulonephritis, asthma, Kv1.3 potassium channel expression is up-regulated,closely related to the mechanism of those disease.In the cardiovascular system diseases, Kv1.3 potassium channel protein is related to the differentiation of monocyte derived macrophage into foam cells, and vascular remodeling.In addition Kv1.3 potassium channel plays a role in apoptosis.This paper provide new ideas for the diagnosis and treatment of T lymphocytes mediated disease, cardiovascular disease and neoplasms.
