Advances in stem cell treatment for bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2015.06.002
- VernacularTitle:干细胞治疗支气管肺发育不良新进展
- Author:
Yuchen SUN
- Publication Type:Journal Article
- Keywords:
Bronchopulmonary dysplasia;
Mesenchymal stem cell
- From:
International Journal of Pediatrics
2015;42(6):607-611
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia(BPD) is a chronic lung disease of prematurity mainly affecting preterm infants with low birth weights, especially those treated with mechanical ventilation and oxygen therapy.There is no specific treatment for BPD until now.Administration of mesenchymal stem cells seems to be an promising novel treatment.Mesenchymal stem cell(MSC) can attenuate lung injury in an amount of animal experiments.But the mechanism is unclear yet.The best dose, timing and the application route of transplantation as the standard treatment strategy is still unresolved.The phase Ⅰ clinical trail shows short-term safety and efficacy of MSC administration.Phase Ⅱ trails and long-term safety studies are under way.This review focuses on the recent achievement in treating BPD with MSC transplantation.
