Research progress on the relationship between FOXM1 and neo-plasm metabolism

VernacularTitle:FOXM1与肿瘤代谢关系的研究进展
Author: Yi ZHANG ; Xiaojuan YE
Publication Type:Journal Article
Keywords: FOXM1; neoplasms; metabolism; glycolysis; oxidative stress
From: Chinese Journal of Clinical Oncology 2015;42(22):1108-1111
CountryChina
Language:Chinese
Abstract: FOXM1 is a member of the FOX family of transcription factors and has been confirmed to participate in cell prolifera-tion and cell cycle progress. FOXM1 has been reported to play an important role in more than 20 types of human neoplasms, and its up-regulation promotes tumor cell proliferation, invasion, metastasis, chemotherapy drug resistance, and resistance to apoptosis. In recent years, various studies have shown that FOXM1 also plays an important role in tumor metabolism. The metabolism of cancer cells deter-mines the growth and survival of cancer, and metabolic alteration is a key feature of tumor cells. The connection between metabolic ab-normalities and tumorigenesis has been reported. The O-linkedβ-N-acetylglucosamine transferase regulates the expression of FOXM1, which helps tumor cells survive without damage caused by oxidative stress. This review aims to summarize the known relationships of FOXM1 and tumor cell metabolism, as well as its role in the potential pathways of tumor metabolism.