Oxidative stress in diabetic peripheral neuropathy
10.3760/cma.j.issn.1000-6699.2015.11.017
- VernacularTitle:氧化应激与糖尿病周围神经病变的研究进展
- Author:
Qian ZHANG
;
Xiaochun LIANG
- Publication Type:Journal Article
- Keywords:
Diabetic peripheral neuropathy;
Oxidative stress;
Reactive oxidative species
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(11):1000-1003
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress play a key role in the pathogenesis of diabetic peripheral neuropathy.Reactive oxidative species(ROS), derived from hyperglycemia through abnormal mitochondrial electron chain and NADPH oxidase et al, may damage lipids, DNA, and proteins by oxidation.ROS can also promote other classical mechanisms of diabetic peripheral neuropathy, and further cause apoptosis of neurons and Schwann cells, or inflammation of nerve tissue, and finally lead to nerve injury.The relationship between oxidative stress and mechanisms of diabetic peripheral neuropathy was reviewed in this article, in order to get a clue for more effective treatment strategies.
