Study on effect of Dl-3n-butylphthalide in treating with delayed encephalopathy after severe carbon monoxide poisoning

VernacularTitle:丁苯酞预防一氧化碳中毒迟发性脑病效果观察
Author: Jing CHEN ; Zhaoxia QIN ; Weiguo LI ; Aijun LI
Publication Type:Journal Article
Keywords: Butylphthalide; Carbon monoxide poisoning; Delayed encephalopathy
From: Clinical Medicine of China 2015;31(12):1099-1101
CountryChina
Language:Chinese
Abstract: Objective To evaluate the prevention and treatment effect of butylphthalide injection in delayed encephalopathy after severe carbon monoxide poisoning(DESCMP).Methods One hundred and fiftyeight cases with severe carbon monoxide poisoning (SCMP) were randomly assigned to 2 groups.Observation group (n =83), butylphthalide treatment when SCMP was diagnosed;Control group (n =75), with no butylphthalide therapy.Incidence rate in 3 month, drug amount and the clinical effects of butylphthalide were observed.Results Observation group occurred 5 DEACMP, with the incidence rate of 6.58％, and control group occurred 14 cases,with the incidence rate of 18.67％ ,significant difference was observed in two groups(x2 =154.204,P＜0.05).There were also significant differences in the glasgow coma scale(14.00±1.89 vs.13.00 ±3.30,t =1.780, P＜ 0.05) and mini-mental state examination (26.20± 2.89 vs.19.57 ± 7.12, t =2.003, P＜0.05) between the two groups.Conclusion Early treatment with butylphthalide can decrease the incidence rate of DEACMP.