Association of growth responses during growth hormone treatment in short children with small for gestational age with their serum insulin-like growth factor-1 and IGF-binding protein-3 levels
10.3760/cma.j.issn.1000-6699.2015.11.011
- VernacularTitle:生长激素治疗小于胎龄矮小患儿的疗效与血清胰岛素样生长因子Ⅰ、胰岛素样生长因子结合蛋白3水平的相关性研究
- Author:
Jingyang ZHENG
;
Feng LIN
;
Erli QU
;
Qing CHEN
- Publication Type:Journal Article
- Keywords:
Growth hormone;
Insulin-like growth factor 1;
Insulin-like growth factor-binding protein-3;
Small for gestational age
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(11):974-976
- CountryChina
- Language:Chinese
-
Abstract:
The efficacy of growth hormone (GH) treatment in short children with small for gestational age (SGA) was evaluated and the association of serum insulin-like growth factor-1 (IGF) and IGF-binding protein-3 (IGFBP-3) levels with height increments was investigated.Fifty-five short children with SGA in our hospital from Sep 2009 to Sep 2013 were collected.Before GH treatment, insulin and arginine stimulation test were performed.The children were treated with recombinant GH with 0.15 U · kg-1 · d-1 for at least 12 months.After GH treatment, the height was (120.5 ± 17.63) cm, height SDS was (-1.53 ± 1.04) SDS, HtSDS was-2.04 ± 0.47, bone age was (6.19 ± 2.34) year, growth velocity was (7.24 ± 1.19) cm/year, all these parameters were significant higher than those before GH treatment.Pre-treatment serum levels of IGF-Ⅰ and IGFBP-3 were negatively correlated with post treatment growth velocity(r =-0.37 and r =-0.31;P =0.004 and P =0.021).GH treatment could effectively improve the height of short children with SGA.Children with lower pre-treatment serum levels of IGF-Ⅰ and IGFBP-3 may reach the higher growth velocity.
