Prognostic value of maximum standard uptake of pretreatment 18F-FDG PET-CT in newly diagnosed soft tissue sarcoma
10.3760/cma.j.issn.1006-9801.2015.10.006
- VernacularTitle:治疗前18F-FDG PET-CT最大标准摄取值在软组织肉瘤中的预后价值
- Author:
Chongyang DING
;
Wenping YANG
;
Jin SUN
;
Yangyang LI
;
Wei YANG
;
Tiannyu LI
- Publication Type:Journal Article
- Keywords:
Soft tissue sarcoma;
Tomograph,emission-computed;
Tomograph,X-ray computed;
Prognosis
- From:
Cancer Research and Clinic
2015;27(10):673-676
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the prognostic value of maximum standard uptake (SUVmax) of pretreatment 18F-FDG PET-CT in patients with newly diagnosed soft tissue sarcomas (STS).Methods The clinical data of 34 patients with STS undergoing 18F-FDG PET-CT before treatment were analyzed retrospectively.The relationship between SUVmax of PET-CT and prognostic factors was evaluated by MannWhitney' s non-paraetric test and Spearman' s rank correlation test.The prognostic factors were analyzed by univariate and multivariate analysis.Results Among 34 patients, the median SUVmax was 10.3 (1.5-28.2), and the median maximum diameter was 6.7 cm (1.8-17.2 cm) with positively association between them (r =0.389, P =0.028).SUVmax was also associated with pathological grade, AJCC staging and distant metastasis, respectively (all P ＜ 0.05).In univariate analysis, distant metastasis, pathological grade, AJCC staging, and SUVmax were found to be the prognostic factors (all P ＜ 0.05).Multivariate analysis results indicated that only the SUVmax and distant metastasis were the independent unfavorable prognostic factors (both P ＜ 0.05).Conclusions The SUmax of pretreatment 18F-FDG PET-CT is well correlated with prognostic factors, and it can predict the prognosis of patients with STS.
