Effect of lactulose oral solution combined with PEG-4000 electrolyte lavage solution on bowel preparation before colonoscopy
10.3760/cma.j.issn.1007-5232.2015.06.005
- VernacularTitle:乳果糖口服液联合聚乙二醇电解质散进行结肠镜肠道准备效果临床观察
- Author:
Fangxu LIU
;
Le XU
- Publication Type:Journal Article
- Keywords:
Colonoscopy;
Bowl preparation;
Lactulose;
Polyethylene Glycols
- From:
Chinese Journal of Digestive Endoscopy
2015;32(6):375-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effectiveness of lactulose oral solution combined with PEG-4000 electrolyte lavage solution with PEG-4000 electrolyte lavage solution only in colonoscopy preparation.Methods A total of 121 patients preparing for colonoscopy were randomly divided into two groups:61 patients in lactulose oral solution combined with PEG-4000 electrolyte lavage solution group (the experimental group =group A),and 60 patients in PEG-4000 electrolyte lavage solution group(the control group =group B).During the colonoscopy,the endoscopist blindly scored the cleanness of the bowel,and recorded any adverse event to assess the safety.Results According to the Boston bowel preparation scale,the experimental group scored 7.07 ±0.79,and the control group scored 6.18 ± 1.03,which showed significant significance(P =0.000).There was no significant difference in the time of accessing rectum between the two groups[(8.80 ± 1.74) min VS(9.22 ± 1.94) min,P =0.220].Polyp detection rate in group A was higher than that in group B,with no significant difference (22.95％ VS 15.00％,P ＞ 0.05).The small polyp (≤0.5 cm)detection rate in group A was higher than that in group B with significant significance(P =0.038).No adverse event was recorded in either group.Conclusion The bowel preparation with lactulose oral solution combined with PEG-4000 electrolyte lavage solution is more effective than that with PEG-4000 electrolyte lavage solution alone.It will enhance the detection rate of small polyps with no evident adverse reactions.
