Application of MDRD and CKD-EPI equations in patients with peripheral arterial diseases
10.3760/cma.j.issn.1001-7097.2015.10.006
- VernacularTitle:MDRD与CKD-EPI肾小球滤过率评估公式在外周动脉疾病患者中的应用
- Author:
Siyun YU
;
Jue LI
;
Lijuan ZHANG
- Publication Type:Journal Article
- Keywords:
Glomerular filtration rate;
Peripheral vascular diseases;
MDRD equation;
CKD-EPI equation
- From:
Chinese Journal of Nephrology
2015;31(10):755-759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the performance of newly developed Chronic Kidney Disease Epideniology Collaboration (CKD-EPI) equation and Modification of Diet in Renal Disease (MDRD) equation in patients with peripheral arterial diseases (PAD).Methods A total of 841 patients with PAD were enrolled in this retrospective cohort study.Estimated glomerular filtration rate (eGFR), calculated by MDRD and CKD-EPI equation respectively, was analyzed by Spearman correlation analysis, Bland-Altman method and Kappa test for the evaluation of correlation and consistency.Net reclassification improvement (NRI) was adopted to compare the death risk assessment between these two equations.Results Although the eGFR was 4.33 ml· min-1 · (1.73 m2)-1 higher with MDRD equation than with CKD-EPI equation, there were still significant correlation and fine consistency between eGFRMDRD and eGFRCKD-EPI (Kappa: 0.749, r=0.991, P＜0.05).The CKD-EPI equation re-classified 9 (1.1％) patients upward to higher eGFR category and 143 (17.0％) patients downward to lower eGFR category.Besides, the performance of risk assessment for all-cause death was better with CKD-EPI equation than with MDRD equation (NRI=0.059, P ＜ 0.05), which was not the case for cardiovascular death (NRI=0.022, P ＞ 0.05).Conclusions There is no solid evidence suggesting that CKD-EPI equation performs better than MDRD equation.
