Clinical analyses of 11 cases with pituitary stalk interruption syndrome

VernacularTitle:垂体柄中断综合征11例临床分析
Author: Yinghui ZHANG ; Bing WANG ; Zhizhen LI ; Xiaojun MA ; Dabei FAN ; Guijun QIN
Publication Type:Journal Article
Keywords: Pituitary diseases; Pituitary stalk interruption syndrome
From: Chinese Journal of General Practitioners 2015;14(9):691-694
CountryChina
Language:Chinese
Abstract: Eleven male patients with pituitary stalk interruption syndrome (PSIS) at our hospital were retrospectively analyzed with respects to clinical features,endocrine status and imaging characteristics.The clinical manifestations included growth retardation and delayed puberty.All of them were deficient in growth hormone and pituitary gonadotropin secretion.Secondary hypothyroidism and hypocortisolism occurred in 8 patients and one had concurrent central diabetes insipidus.MRI with gadolinium contrast revealed no pituitary stalk or slim and anterior pituitary hypoplasia with ectopic posterior pituitary.The clinical characteristics of PSIS are growth retardation and delayed puberty,partial or complete adenohypophyseal dysfunction.The detection of hypothalamic pituitary region by MRI is an important diagnostic tool.