Application of ultrasonography in diagnosing and preoperative TNM staging for neuroendocrine breast cancer
10.3760/cma.j.issn.1004-4477.2015.10.020
- VernacularTitle:超声在乳腺神经内分泌癌诊断与术前TNM分期中的应用
- Author:
Xiaoshuang CHEN
;
Liwu LIN
;
Ensheng XUE
;
Zhikui CHEN
;
Yimi HE
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Breast neoplasms;
Neuroendocrine tumors;
Neoplasm staging
- From:
Chinese Journal of Ultrasonography
2015;24(10):894-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of ultrasonography in diagnosis and preoperative TNM staging for neuroendocrine breast cancer(NEBC).Methods The ultrasonic characteristics of 12 NEBC and 104 invasive ductal carcinoma(IDC) confirmed by pathology,as well as the metastatic lymph nodes were analyzed retrospectively.The TNM-staging for NEBC by preoperative ultrasonography was evaluated according to pathology.And the relation between lesions size and Ki-67 was then analyzad.Results NEBC lesions mainly showed solid and heterogeneous hypoechoic(66.67％),irregular shape(66.67％),clear border (58.33 ％),posterior enhancement(58.33 ％) and internal blood flow(grade 0-Ⅰ) (66.67 ％).The detection rate of unclear border,irregular edge,hyperechoic halos and uneven internal echo was lower than IDC(P ＜ 0.05).Meanwhile,NEBC had a lower detection rate of calcification and internal blood flow(grade Ⅱ-Ⅲ)than IDC (P ＞0.05).And the detection rate of more round or oval lesions were higher in NEBC than that in IDC (P =0.001).According to pathology,the ultrasonic coincidence rate for T staging of NEBC and pathology was 75％,and for T1-staging was 100％,for T2-staging was 80％.The sensitivity,specificity,positive predictive value and negative predictive value of ultrasonic diagnosis on lymph node metastases was 66.67％,88.89％,66.67％ and 88.89％,respectively.There was a positive correlation between focal maximum diameter with Ki-67 (r=0.026,P=0.004).Conclusions It shows certain value of ultrasonography in diagnosis and preoperative TNM staging for NEBC.
