β-catenin and PCNA expression in gastric cancer tissues and their correlation with clinical prognosis
10.3760/cma.j.issn.1007-631X.2015.08.015
- VernacularTitle:β-连环蛋白与增殖细胞核抗原在胃癌中的表达及其与预后的关系
- Author:
Jupeng YANG
;
Daguang WANG
;
Yagang LI
;
Zhenguo XU
;
Jian SUO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Proliferating cell nuclear antigen;
beta-Catenin
- From:
Chinese Journal of General Surgery
2015;30(8):635-638
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of β-catenin and PCNA,and its relationship with clinical parameters and prognosis.Methods Tissue microarray technology and immunohistochemical method were used to detect the expression of β-catenin and PCNA in gastric carcinoma and normal tissue collected from January 2000 to December 2006.Data were analyzed by SPSS 19.0.Results The percentage of expression of β-catenin and PCNA in gastric carcinoma is 96.7％,99.2％,respectively,and higher than the normal gastric tissue (x2 =41.082,P =0;x2 =97.692,P =0).ROC curve was used to find that PCNA was better than β-catenin to discriminate gastric carcinoma from normal gastric tissue in sensitivity,specificity,coincidence rate(84.4％,87.5％,84.6％).The expression of β-catenin is related to lymph node metastasis in gastric cancer (x2 =6.107,P =0.04).The expression of PCNA is related to pathological type (x2 =9.71,P =0.02).The expression of β-catenin and PCNA in gastric carcinoma were positively correlated (r =0.24,P =0.005).Multivariate analysis showed that TNM staging and both positive β-catenin and PCNA were independent factors impacting on the overall survival rate of patient with gastric cancer.Conclusions The expression of β-catenin and PCNA in gastric carcinoma is signifrcandy high.PCNA is more important than β-catenin in discriminating gastric carcinoma from normal gastric tissue.Combined detection of the two kinds of protein have some clinical significance in predicting the prognosis of patients with early gastric cancer.
