The relationship between ABI1 upregulation and clinicopathological features and prognosis of colorectal adenocarcinoma
10.3760/cma.j.issn.1007-631X.2015.08.017
- VernacularTitle:ABI1表达上调与结直肠腺癌临床病理及预后的相关性分析
- Author:
Kun LI
;
Mei LI
;
Yulan LIU
;
Shuyun MA
;
Weidong YU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Pathology,clinical;
Prognosis;
Immunohistochemistry
- From:
Chinese Journal of General Surgery
2015;30(8):643-646
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the expression of Abl interactor 1 (ABI1) and the clinicopathologic characteristics in colorectal adenocarcinoma tissues.Methods Immunohistochemistry was used to determine ABI1 expression in human colorectal adenocarcinoma tissues and matched adjacent tissues.A statistical analysis was used to determine the potential correlation between ABI1 expression and clinicopathological characteristics and prognosis.Results ABI1 is up-regulated in colorectal adenocarcinoma tissues compared with matched adjacent tissues (P =0.000),ABI1 expression is significantly correlated with infiltration (P =0.043) and differentiation (P =0.040),but not with sex,age,tumor location,clinical stage,lymph node metastasis and distant metastasis (P ＞0.05);It was also shown that ABI1 expression had a significant influence on prognosis (x2 =11.090,P =0.001).Multivariate analyses showed that high ABI1 expression is not an independent poor prognostic factor for overall survival (P =0.119).Conclusion ABI1 overexpression might act as pro-oncogene for patients with colorectal adenocarcinoma.
