Efficacy of oxycodone or hydromorphone combined with propofol for colonoscopy
10.3760/cma.j.issn.0254-1416.2015.06.021
- VernacularTitle:羟考酮或氢吗啡酮复合异丙酚麻醉用于结肠镜诊疗术的效果
- Author:
Yingying CHEN
;
Zongze ZHANG
;
Hanxing LIU
;
Chang CHEN
;
Lingxue ZHOU
;
Yanlin WANG
- Publication Type:Journal Article
- Keywords:
Oxycodone;
Hydromorphone;
Propofol;
Colonoscopy
- From:
Chinese Journal of Anesthesiology
2015;35(6):724-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of oxycodone or hydromorphone combined with propofol for colonoscopy.Methods A total of 150 patients of both sexes,aged 18-64 yr,weighing 45-85 kg,of ASA physical status Ⅰ or Ⅱ,undergoing colonoscopy,were randomly divided into 3 groups (n=50) using a random number table:fentanyl combined with propofol group (group F),oxycodone combined with propofol group (group O) and hydromorphone combined with propofol (group H).In F,O and H groups,fentanyl 1 μg/kg,oxycodone 0.1 mg/kg and hydromorphone 0.02 mg/kg were injected over 60 s,respectively,and then propofol 1.5 mg/kg was injected intravenously.After eyelash reflex disappeared,a colonoscope was placed.When body movement occurred during examination,half of the initial dose of propofol was added.The time for induction of anesthesia,operation time,emergence time,recovery time,occurrence of adverse cardiovascular events,nausea and vomiting and respiratory depression,and amount of propofol consumed were recorded.Results There was no significant difference between the three groups in the time for induction of anesthesia,operation time,emergence time,recovery time,adverse cardiovascular events,respiratory depression,and amount of propofol consumed.Compared with group F,the incidence of nausea and vomiting and respiratory depression was significantly decreased,and the degree was reduced in H and O groups.No significant difference was found between group O and group H in the incidence of nausea and vomiting and respiratory depression and the degree.Conclusion Oxycodone or hydromorphone combined with propofol can be safely and effectively used for colonoscopy and the efficacy is better than that of fentanyl combined with propofol.
