Impact of living donor nephrectomy on the early kidney function for donors
10.3760/cma.j.issn.1001-7097.2015.07.002
- VernacularTitle:活体肾移植供肾切除术对供体早期肾功能的影响
- Author:
Qiuqin CAI
;
Wenqing XIE
;
Dicui YAO
;
Jun YE
;
Rending WANG
;
Jianyong WU
;
Jianghua CHEN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Nephrectomy;
Uric acid;
Creatinine;
Living donor Nephrectomy;
Urine microprotein
- From:
Chinese Journal of Nephrology
2015;31(7):487-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the early renal function of donors after nephrectomy.Methods Clinical data of 467 cases of living kidney donors during the period from April,2010 and November,2014 in our center were retrospectively analyzed.Data on serum creatinine (Scr),glomerular filtration rate (GFR),serum uric acid (UA),and urine microproteins before operation and three days,seven days,one month and three months after operation were collected to evaluate the impact of nephrectomy on early renal function after operation for donators.Results Before operation and three days,seven days,one month,three months after operation,the average serum creatinine (Scr) level was (59.9±12.8),(85.8±21.0),(91.2±21.3),(92.8±21.6),(91.0±21.3) μmol/L,respectively; The GFR were (113.5±25.3),(75.1± 17.9),(70.3± 15.2),(68.5± 16.0),(69.5± 15.1) ml/min,respectively; The levels of uric acid were (292.60±79.58),(142.18±55.28),(228.41±66.39),(321.31± 83.72),(346.61±87.21) μmol/L,respectively; All these data above-mentioned after operation reached statistical significance compared with that before operation (P ＜ 0.05).Parameters including urine IgG,urine albumin,urine retinol-binding protein and urine β2-microglobulin post-operation time point were significantly different when compared with relative parameters pre-operation (P ＜ 0.05).Conclusions Nephrectomy has significant influence on GFR,uric acid,and urine microprotein for donors in the early stage after operation.It's worth to evaluate nephrectomy's long-term effect on the renal function of donors in clinical practice.
