Serum hepatocyte growth factor and severity of type 2 diabetic nephropathy

VernacularTitle:不同2型糖尿病肾病患者血清肝细胞生长因子水平的观察
Author: Hong ZHU ; Tieqi LIU
Publication Type:Journal Article
Keywords: Hepatocyte growth factor; Diabetic nephropathies
From: Chinese Journal of General Practitioners 2015;14(10):765-767
CountryChina
Language:Chinese
Abstract: To explore the serum hepatocyte growth factor (HGF) lesion severity level and diabetic nephropathy (DN).A total of 207 patients with type 2 diabetes mellitus (T2DM) were recruited from Second Municipal Hospital.According to the level of urinary albumin excretion rate (UAER), they were divided into non-DN group (group A, n =56) : UAER ＜ 20 μg/min;early DN (group B, n =55) : UAER: 20-200 μg/min;clinical stage DN with normal renal function (group C, n =52):UAER ＞ 200 μg/min;DN in clinical renal dysfunction (group D, n =44) : UAER ＞ 200 μmol/min, decompensated chronic renal failure (serum creatinine: 133-177 μmol/L).And 55 healthy subjects were selected as controls.The serum levels of HGF, fasting plasma glucose , plasma glucose at 2 hour , blood urea nitrogen, creatinine and glycosylated hemoglobin were determined.HGF value : control group : (256.4 ± 30.4) ng/L,group A: (400.1 ±39.3)ng/L, group B: (689.4 ±55.6) ng/L, group C:(967.3 ±68.5) ng/L and group D: (150.7 ±23.2) ng/L.There are differences of serum HGF in different degree of DN.