Abnormal expression of proto-oncogene YES-associated protein in gastric cancer tissues in the elderly and its correlation with the poor prognosis
10.3760/cma.j.issn.0254-9026.2015.08.015
- VernacularTitle:老年人胃癌组织中原癌基因Yes相关蛋白异常表达及其与预后不良的相关性
- Author:
Qingbo FAN
;
Bingyu QIN
;
Cunzhen WANG
;
Han LIU
;
Weiqing LIU
;
Huifeng ZHANG
;
Jianjian CHENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Proto-oncogene proteins
- From:
Chinese Journal of Geriatrics
2015;34(8):881-883
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the abnormal expression of proto-oncogene YES-associated protein (YAP) in gastric cancer tissues in the elderly and its correlation with poor prognosis.Methods Clinical data of 80 elderly patients with gastric cancer treated in our hospital from March 2011 to October 2014 were statistically analyzed.Results The positive expression rate of YAP was significantly higher in gastric carcinoma than in adjacent tissues [71.3％ (57/80) vs.13.8％ (11/80),P＜0.05].The positive expression of YAP were significantly associated gastric tumor size,tumor stage,invasion depth and lymph node metastasis (all P＜0.05),but had no correlation with tumor differentiation (P＞0.05).The 5-year survival rate was significantly lower in patients with YAP-positive expression than in patients with YAP-negative expression (P ＜ 0.05),but the differences in 1-year,3-year survival rates were not significant between the two groups (all P＞0.05)The YAP expression,tumor stage,lymph node metastasis were significantly associated with the prognosis of gastric cancer in patients (all P＜0.05).Conclusions YAP-positive expression rate is significantly higher in gastric cancer tissues than in adjacent tissues in the elderly,which indicates poor prognosis of patients with gastric cancer.
