Progress on the clinical research of fluoro-3(2(S)-2-azetidinylmethoxy) pyridine and Iodo-3-(2(S)-azetidinylmethoxy) pyridine

VernacularTitle:氟化及碘化3-[2(S)-氮杂环丁烷甲氧基]吡啶的临床研究进展
Author: Yuyan JIANG ; Yafu YIN ; Yaming LI
Publication Type:Journal Article
Keywords: Receptors,nicotinic; Pyridines; Radionuclide imaging; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2015;35(4):322-325
CountryChina
Language:Chinese
Abstract: Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a spectrum of cognitive functions and related to some psychiatric and neurodegenerative disorders such as AD,PD,autosomal dominant nocturnal frontal lobe epilepsy and schizophrenia.Nuclear medicine imaging of neuronal nAChRs in living human is a relatively new field.Halogenated analogs of 3 (2 (S)-2-azetidinylmethoxy) pyridine (A-85380) are the most widely used brain imaging radiotracers.In this review,the progress on the latest research on SPECT and PET using the analogs of A-85380 is summarized.