The study of relationship between smoking and symptomatic osteoarthritis of weight-bearing or axial joints
10.3760/cma.j.issn.1007-7480.2015.08.004
- VernacularTitle:主被动吸烟对中轴及承重关节症状性骨关节炎交互作用影响研究
- Author:
Fangchao LIU
;
Junfeng ZHANG
;
Guifen LIU
- Publication Type:Journal Article
- Keywords:
Osteoarthritis;
Smoking;
Interaction
- From:
Chinese Journal of Rheumatology
2015;19(8):518-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the effec.t of smoking and related factors in symptomatic osteoarthritis disease,and explore the method to analyze the osteoarthritis (OA) risks.Methods Based on the investigation of 7 126 rural residents in Shanxi province,according to whether patients had related factors of symptomatic osteoarthritis in longitudinal axis arthrosis,the single factor and multiple factors logistic regression analysis were adopted to reveal the interaction between risk factors,and the interaction on multiplicative scale and the interaction on additive scale were both analyzed;interaction on multiplicative scale was estimated by OR,the interaction on additive scale was estimated by the relative excess risk due to interact (RERI),the attributableproportion due to interaction (AP),and the synergy index (S).Results The survey included 7 126 residents,in which 1 480 cases osteoarthritis patients in vertical axis joint with the prevalence of 20.8％.By multiple logistic regression analysis,the whole samples by enter level 0.05 level was stepwisely filtered.The results showed that gender,body mass inlex (BMI),smoking,age,heatable adobe,picky eater,working under coal mine were main influencing factors for the symptomatic arthritis.Balance other influence factors,passive smoking had an effect on arthritis.Aftcr adjusting for weight,smoking was not included in the final model.In the stratified interaction analysis,there was interaction on multiplicative scale between smoking and weight (OR=0.32,P=0.03),and the interaction on additive scale between passive smoking and gender or weight exists [RERI (95％CI) 0.41 (0.01,0.81)＞0,AP(95％CI) 0.25(0.01,0.51)＞0,S=3.04＞ 1].Conclusion The influence of smoking on osteoarthritis is so weak that it could not be a risk factor and its influence on osteoarthritis is initiated via body.
