Clinical analysis of polymyositis/dermatomyositis complicated with venous thromboembolism: a report of 23 cases
10.3760/cma.j.issn.1007-7480.2015.08.005
- VernacularTitle:多发性肌炎/皮肌炎伴发静脉血栓栓塞23例临床分析
- Author:
Pang CHEN
;
Xin WANG
;
Qian WANG
;
Wenjie ZHENG
- Publication Type:Journal Article
- Keywords:
Polymyositis;
Dermatomyositis;
Venous thromboembolism;
Retrospective studies
- From:
Chinese Journal of Rheumatology
2015;19(8):524-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of polymyositis/dermatomyositis (PM/DM) complicated with venous thromboembolism (VTE).Methods Medical records of patients with PM/DM at Peking Union Medical College Hospital from Jan 2000 to Oct 2014 were reviewed to identify VTE.The comparisons of various categorical clinical manifestations between groups were evaluated using t-test and x2 test.Results Twenty-three PM/DM patients developed VTE,which accounted for 1.86％ of the 1 235 PM/DM patients hospitalized during the same period.Among these 23 patients (18 female and 5 male),5 patients had PM and 18 patients had DM.With respect to the occurrence of VTE,no significant difference was found between DM and PM or between male and female.Their age was (57±7) years (range:47-71 years old),significantly older than patients without thrombosis [(47±13) years,t=-3.191,P=0.001].Twenty-one patients (75％,21/28) developed VTE in the first year after the diagnosis of PM/DM.The incidence rate ratios (IRR) for DVT in PM/DM were 1.46％ (18/1 235) and for PTE was 0.73％ (9/1 235),in which 4 cases complicated with lower extremity DVT.Most patients exhibited active disease and high levels of D-Dimer during the emergence of VTE.Conclusion Patients with PM/DM have an increased risk of VTE,especially in older patients and at the early stage after the diagnosis of PM/DM,indicating that more attention should be paid to these patients in the clinic.
