Predictive value of NT-proBNP in anthracycline-based chemotherapy-related cardiotoxicity of breast cancer
10.3760/cma.j.issn.1008-1372.2015.10.021
- VernacularTitle:N末端B型脑利钠肽前体对乳腺癌蒽环类化疗相关心脏毒性的预测价值
- Author:
Huidong LONG
;
Yunen LIN
;
Guancheng LIU
;
Bingchuan YAN
;
Bangshun LIANG
;
Zhiwei LIAO
;
Shilei DAI
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain/ME;
Breast neoplasms/ME/DT;
Anthracyclines/TU/AE;
Heart/DE
- From:
Journal of Chinese Physician
2015;17(10):1516-1519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level in anthracycline-based chemotherapy-related cardiotoxicity of breast cancers.Methods A total of 135 breast cancer patients was analyzed if NT-proBNP was associated with chemotherapy-related cardiotoxicity.The level of NT-proBNP in the diagnosis of cardiotoxicity was assessed.Results A total of 22 patients (16.29%) had subsequent claims for cardiotoxicity events.NT-proBNP in cardiotoxicity group was significantly higher than that non-cardiotoxicity group (P < 0.05).According to receiver operating characteristic (ROC) curve, the cut-off value of NT-proBNP was set at 350 pg/ml, specificity and sensitivity were 70.32% and 82.58% , respectively.Positive and negative predictive values were 78.12% and 65.45%, respectively.Conclusions The present study is to confirm excellent clinical value of NTproBNP on cardiotoxicity.The level of NT-proBNP for early detection of cardiotoxicity has good prospects for high risk patients.