Prognostic value of combination of N-terminal B-type brain natriuretic peptide and galectin-3 in patients with chronic heart failure
10.3760/cma.j.issn.1008-1372.2015.09.016
- VernacularTitle:NT-proBNP联合galectin-3对慢性心力衰竭患者预后的评估价值
- Author:
Qinghua FU
;
Sulan YAN
;
Ying GUO
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain/AD;
Galectin 3/AD;
Heart failure/DT
- From:
Journal of Chinese Physician
2015;17(9):1347-1350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate prognostic value of N-terminal B-type brain natriuretic peptide (NT-proBNP) combined with galectin 3 of prognostic value in patients with chronic heart failure (CHF).Methods Determination of 92 cases of CHF patients on admission and at discharge plasma NT-proBNP and galectin-3 levels,then after the patients discharge we follow up 16 months and observe the internal recurrent heart failure hospitalization rate and mortality.Results In patients the heart function of New York Heart Association (NYHA) Ⅰ,Ⅱ,Ⅲ,Ⅳ level,NT-proBNP were (351.6 ± 467.5) pg/ml,(493.2 ± 411.7) pg/ml,(1 289.6 ± 737.8) pg/ml,(2 719.2 ± 1 044.1) pg/ml,galectin-3 (12.23 ± 6.12) ng/ml,(13.59± 5.46) ng/ml,(19.18 ± 7.44) ng/ml,(26.61 ± 8.82) ng/ml as well.NT-proBNP and galectin-3 levels were increased with the depression of cardiac function.The patients who had higher NT-proBNP or galectin3 levels discharged and occurred the more probability of re-hospitalization on account of heart failure or death.Compared to those patients with one of them increased,the patients whose discharge NT-proBNP and galectin-3 value were both increased with significantly poor outcome.Conclusions Both NT-proBNP and galectin-3 were independent predictors of poor prognosis in patients with heart failure.Galectin-3 combined with NT-proBNP can assess the prognosis of patients with CHF more effectively.
