The expression and significance of MTA1, MMP-9, and VEGF-C in the gastric adenocarcinoma
10.3760/cma.j.issn.1008-1372.2015.10.015
- VernacularTitle:MTA1、MMP-9和VEGF-C在胃腺癌中的表达及意义
- Author:
Zhibin BI
;
Wenqing HU
;
Lili MA
;
Lina LI
- Publication Type:Journal Article
- Keywords:
Repressor proteins/ME;
Histone deacetylases/ME;
Matrix metalloproteinase 9/ME;
Vascular endothelial frowth factor C/ME;
Stomach neoplasms/ME
- From:
Journal of Chinese Physician
2015;17(10):1494-1497
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinicopathological significance of metastasis-associated 1 (MTA1), matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor-C (VEGF-C) in a gastric adenocarcinoma.Methods The expressions of MTA1, MMP-9, and VEGF-C were detected with immunohistochemical method in 120 cases of gastric adenocarcinoma tissues and 30 cases of normal gastric tissues.Results The positive percentage of MTA1, MMP-9, and VEGF-C proteins in gastric adenocarcinomas was 76.7％ , 71.7％ , and 64.2％ , respectively, which was significantly higher than that (33.3％, 36.7％, and 30.0％) in normal gastric mucosa tissues (P ＜0.05).The expressions of MTA1, MMP-9, and VEGF-C were significantly higher in gastric carcinoma invasion serous membrane, lymph node metastasis, clinical Ⅲ ～ than that in non-invasion serous membrane, non-lymph node metastasis, and clinical Ⅰ ～ Ⅱ (P ＜ 0.05).The expression of MTA1 had significantly positive correlation with that of MMP-9 (P ＜ 0.05) and VEGF-C (P ＜ 0.05) in gastric adenocarcinomas.Conclusions The expressions of MTA1, MMP-9, and VEGF-C were higher in gastric adenocarcinomas than normal gastric mucosa tissues.They may play an important role in the invasion and metastasis of gastric carcinomas.MTA1 may promote infiltration, invasion, and lymph node metastasis of gastric carcinoma through regulation of the expressions of MMP-9 and VEGF-C.The combined detection of MTA1, MMP-9, and VEGF-C expressions has important value to judge the grade malignance of gastric adenocarcinomas.
