The correlations of LRP and GST-π to chemotherapy resistance and prognosis of ovarian cancer
10.3760/cma.j.issn.1008-1372.2015.09.022
- VernacularTitle:LRP、GST-π表达与卵巢癌化疗耐药及预后的关系
- Author:
Xinying QI
;
Fengzhen YANG
;
Na WANG
;
Zhengmao ZHANG
- Publication Type:Journal Article
- Keywords:
Vault ribonucleoprotein particles/ME;
Glutathione transferase/ME;
Ovarian neoplasms/ME/DT;
Drug resistance,neoplasm;
Prognosis
- From:
Journal of Chinese Physician
2015;17(9):1372-1375
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlations of lung resistance protein (LRP) and glutathione S transferase π (GST-π) to chemotherapy resistance and prognosis of epithelial ovarian cancer.Methods The expressions of LRP and GST-π in epithelial ovarian cancer were examined with immunohistochemistry.Correlations of LRP and GST-π to chemotherapy efficacy and survival time after operation were analyzed.Results The short-term efficacy rates of ovarian cancer were lower in patients with positive expressions of LRP and GST-π than those with negative expressions [61.2％,61.7％ vs 94.1％,89.5％,x2 =6.47,4.94,P =0.011,P =0.026].The positive rates of LRP and GST-π were significant higher in patients with chemotherapy resistance than in those sensitive to chemotherapy [91.3％,87.0％ vs 65.1％,62.8％,P ＜ 0.05].Log-rank test showed that patients with positive LRP and GST-π had shorter survival time than those negative,and patients with both positive LRP and GST-π had shorter survival time than those both negative (P ＜ 0.05).Conclusions The expressions of LRP and GST-π in epithelial ovarian cancer could be used to predict chemotherapy resistance and prognosis of patients.
