Study on Effect ofQi-supplementing and Depression-relieving ofJie-Du Tong-LuoCapsule on Post-stroke Depression Rat Model
10.11842/wst.2015.07.009
- VernacularTitle:解毒通络胶囊对中风后抑郁大鼠模型益气解郁功效研究
- Author:
Wenting SONG
;
Li XU
;
Jianxun REN
;
Mingjiang YAO
;
Guangrui WANG
;
Jianxun LIU
- Publication Type:Journal Article
- Keywords:
Jie-Du Tong-Luo capsule;
post-stroke depression;
qi-supplementing and depression-relieving;
efficacy study
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(7):1380-1385
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe behavioral changes of post-stroke depression (PSD) rats, and to assess effect ofJie-Du Tong-Luo(JDTL) capsule onqi-supplementing and depression-relieving. Microspheres were injected from external carotid artery of rats under anesthesia to prepare the multiple cerebral infarction. Aftermid long term feeding, PSD rat model was established. Then, open-field test (OFT), tail suspension test (TST), forced swimming test (FST) and glucose preference test were employed to study behavioral changes of rats. The results showed that rats suffered multiple cerebral infarction after mid long term feeding formed PSD, which were indicated by reduced food consume, slow body weight increasing, reduction of spontaneous movement and inquiry activity, prolonged accumulative immobility time in TST, FST and lowered glucose preference, compared with rats in the normal group. Compared with the model group, rats in the JDTL capsule group andBu-Chang Xin-Nao-Tonggroup showed larger body weight increase, higher scores in OFT, reduced immobility time in TST, FST, and elevated glucose preference. It was concluded that JDTL capsule had significant efficacy on rats’ body weight, behavior and glucose preference, which might be its pharmacological basis onqi-supplementing and depression-relieving.
