Experimental Study on CompoundWeifu in Gout Treatment

VernacularTitle:复方威茯治疗痛风作用的实验研究
Author: Lizhen HUANG ; Lingling YANG ; Jiagang DENG ; Zhengcai DU ; Dong LU
Publication Type:Journal Article
Keywords: CompoundWeifu; gout treatment; inflammatory reaction; experimental study
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(7):1409-1413
CountryChina
Language:Chinese
Abstract: This article was aimed to study the action of antigout effects of compoundWeifu. Through the acute gouty arthritis models of rabbits and rats induced by micro-crystal sodium urate (MSU). The histopathological changes of synovial tissues among rabbits were observed. And the contents of TNF-α, IL-1β, IL-6 in rabbit serum were determined. The swelling degree of the rats’ feet and the content of prostaglandin E2 (PGE2) from the inflammatory exudate foot induced by MSU were also determined. The antigout effects of compoundWeifu were observed. The results showed that the grade of the vascular congestion, swelling and inflammatory cell infiltration in synovial tissues in the high-dose and medium-dose CompoundWeifu group had significantly improved (P <0.05). And the levels of TNF-α, IL-1β, IL-6 in serum were significantly decreased (P< 0.05, orP < 0.01). It can obviously reduce the swelling degree induced by MSU, and the level of PGE2 in the inflammatory exudate foot (P< 0.05, orP < 0.01). It was concluded that CompoundWeifu had obvious antigout effects in the study.