Protective effects of quercetin on the periodontal tissue in rats with periodontitis
10.3969/j.issn.1001-3733.2015.05.005
- VernacularTitle:槲皮素对实验性牙周炎大鼠牙周组织的保护作用
- Author:
Chao GE
;
Dongru YANG
;
Mingxuan WU
;
Chunnian LI
- Publication Type:Journal Article
- Keywords:
Quercetin;
Periodontitis;
Periodontal tissue;
Wistar rat
- From:
Journal of Practical Stomatology
2015;(5):619-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effects of quercetin on the periodontal tissue in Wistar rats with periodontitis. Methods:30 Wistar rats were randomly divided into 3 groups(n =1 0):Control group (group N),ligation group(group L)and liga-tion +quercetin group(group LQ).Bilateral first molars of the rats in group L and LQ were cervically ligated by an orthodontic wire with the diameter of 0.2 mm.The rats in group LQ were then treated with quercetin by gavage at 50 mg/(kg·d)after ligation.After 8 weeks,the rats were killed.Continuous slices of the periodontal tissue were made for HE staining and immunohistochemistry stai-ning.The morphological changes and the expression of TNF-αand COX-2 in the periodontal tissue were observed under light micro-scope.Results:The inflammatory cells and periodontal pocket were observed in group LQ were less than those in group L.The levels of TNF-α,COX-2 in group LQ were lower than that those in the group L(P <0.05).Conclusion:Quercetin has a protective effect on the periodontal tissues of Wistar rats with periodontitis.
